Valproic acid-exposed astrocytes impair inhibitory synapse formation and function

Valproic acid (VPA) is widely prescribed to treat epilepsy. Maternal VPA use is, however, clinically restricted because of the severe risk that VPA may cause neurodevelopmental disorders in offspring, such as autism spectrum disorder. Understanding the negative action of VPA may help to prevent VPA-...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Takeda, Kotomi, Watanabe, Takuya, Oyabu, Kohei, Tsukamoto, Shuntaro, Oba, Yuki, Nakano, Takafumi, Kubota, Kaori, Katsurabayashi, Shutaro, Iwasaki, Katsunori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794250/
https://ncbi.nlm.nih.gov/pubmed/33420078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79520-7
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