Valproic acid-exposed astrocytes impair inhibitory synapse formation and function

Valproic acid (VPA) is widely prescribed to treat epilepsy. Maternal VPA use is, however, clinically restricted because of the severe risk that VPA may cause neurodevelopmental disorders in offspring, such as autism spectrum disorder. Understanding the negative action of VPA may help to prevent VPA-...

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發表在:Sci Rep
Main Authors: Takeda, Kotomi, Watanabe, Takuya, Oyabu, Kohei, Tsukamoto, Shuntaro, Oba, Yuki, Nakano, Takafumi, Kubota, Kaori, Katsurabayashi, Shutaro, Iwasaki, Katsunori
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794250/
https://ncbi.nlm.nih.gov/pubmed/33420078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79520-7
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