p21CIP1 promotes mammary cancer initiating cells via activation of Wnt/TCF1/CyclinD1 signaling

Cancer stem cells (CSCs) generate and sustain tumors due to tumor initiating potential, resulting in recurrence or metastasis. We showed that knockout of the cell cycle inhibitor, p21CIP1, in the PyMT mammary tumor model, inhibits metastasis; however the mechanism remained unknown. Here, we show a p...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Res
Main Authors: Benard, Outhiriaradjou, Qian, Xia, Liang, Huizhi, Ren, Zuen, Suyama, Kimita, Norton, Larry, Hazan, Rachel B.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793565/
https://ncbi.nlm.nih.gov/pubmed/30967481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1044
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