Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors

There are few methods available for the rapid discovery of multi-target drugs. Herein, we describe the template-assisted, target-guided discovery of small molecules that recognize d(CTG) in the expanded d(CTG·CAG) sequence and its r(CUG) transcript that cause myotonic dystrophy type 1 (DM1). A posit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Hagler, Lauren D., Luu, Long M., Tonelli, Marco, Lee, JuYeon, Hayes, Samuel M., Bonson, Sarah E., Vergara, J. Ignacio, Butcher, Samuel E., Zimmerman, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793557/
https://ncbi.nlm.nih.gov/pubmed/32856901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00472
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados