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Replication Inhibitors Modulate Instability of an Expanded Trinucleotide Repeat at the Myotonic Dystrophy Type 1 Disease Locus in Human Cells

Gene-specific CTG/CAG repeat expansion is associated with at least 14 human diseases, including myotonic dystrophy type 1 (DM1). Most of our understanding of trinucleotide instability is from nonhuman models, which have presented mixed results, supporting replication errors or processes independent...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yang, Zhi, Lau, Rachel, Marcadier, Julien L., Chitayat, David, Pearson, Christopher E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society of Human Genetics 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180489/
https://ncbi.nlm.nih.gov/pubmed/14574643
Tagiau: Ychwanegu Tag
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