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Development of novel macrocyclic small molecules that target CTG trinucleotide repeats
We describe the molecular design, synthesis, and investigation of a series of acridine-triaminotriazine macrocycles that selectively bind to CTG trinucleotide repeats in DNA with minimal nonspecific binding. The limited conformational flexibility enforces the stacking of the triaminotriazine and acr...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6592636/ https://ncbi.nlm.nih.gov/pubmed/31113691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.05.022 |
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