Increased prostaglandin-D(2) in male STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation

Cardiac levels of the signal transducer and activator of transcription factor-3 (STAT3) decline with age, and male but not female mice with a cardiomyocyte-specific STAT3 deficiency conditional knockout (CKO) display premature age-related heart failure associated with reduced cardiac capillary densi...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Stelling, Elisabeth, Ricke-Hoch, Melanie, Erschow, Sergej, Hoffmann, Steve, Bergmann, Anke Katharina, Heimerl, Maren, Pietzsch, Stefan, Battmer, Karin, Haase, Alexandra, Stapel, Britta, Scherr, Michaela, Balligand, Jean-Luc, Binah, Ofer, Hilfiker-Kleiner, Denise
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793290/
https://ncbi.nlm.nih.gov/pubmed/33370269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000739
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