Insulin supplementation attenuates cancer-induced cardiomyopathy and slows tumor disease progression

Advanced cancer induces fundamental changes in metabolism and promotes cardiac atrophy and heart failure. We discovered systemic insulin deficiency in cachectic cancer patients. Similarly, mice with advanced B16F10 melanoma (B16F10-TM) or colon 26 carcinoma (C26-TM) displayed decreased systemic insu...

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Foilsithe in:JCI Insight
Main Authors: Thackeray, James T., Pietzsch, Stefan, Stapel, Britta, Ricke-Hoch, Melanie, Lee, Chun-Wei, Bankstahl, Jens P., Scherr, Michaela, Heineke, Jörg, Scharf, Gesine, Haghikia, Arash, Bengel, Frank M., Hilfiker-Kleiner, Denise
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436547/
https://ncbi.nlm.nih.gov/pubmed/28515362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93098
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