Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy

AIMS: The benefit of the β(1)-adrenergic receptor (β(1)-AR) agonist dobutamine for treatment of acute heart failure in peripartum cardiomyopathy (PPCM) is controversial. Cardiac STAT3 expression is reduced in PPCM patients. Mice carrying a cardiomyocyte-restricted deletion of STAT3 (CKO) develop PPC...

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書誌詳細
出版年:Eur Heart J
主要な著者: Stapel, Britta, Kohlhaas, Michael, Ricke-Hoch, Melanie, Haghikia, Arash, Erschow, Sergej, Knuuti, Juhani, Silvola, Johanna M. U., Roivainen, Anne, Saraste, Antti, Nickel, Alexander G., Saar, Jasmin A., Sieve, Irina, Pietzsch, Stefan, Müller, Mirco, Bogeski, Ivan, Kappl, Reinhard, Jauhiainen, Matti, Thackeray, James T., Scherr, Michaela, Bengel, Frank M., Hagl, Christian, Tudorache, Igor, Bauersachs, Johann, Maack, Christoph, Hilfiker-Kleiner, Denise
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
Basic Science
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381590/
https://ncbi.nlm.nih.gov/pubmed/28201733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehw086
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