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Exploiting prior knowledge about biological macromolecules in cryo-EM structure determination

Three-dimensional reconstruction of the electron-scattering potential of biological macromolecules from electron cryo-microscopy (cryo-EM) projection images is an ill-posed problem. The most popular cryo-EM software solutions to date rely on a regularization approach that is based on the prior assum...

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Detalhes bibliográficos
Publicado no:IUCrJ
Main Authors: Kimanius, Dari, Zickert, Gustav, Nakane, Takanori, Adler, Jonas, Lunz, Sebastian, Schönlieb, Carola-Bibiane, Öktem, Ozan, Scheres, Sjors H. W.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793004/
https://ncbi.nlm.nih.gov/pubmed/33520243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252520014384
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