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NaCl cotransporter activity and Mg(2+) handling by the distal convoluted tubule

The genetic disease Gitelman syndrome, knockout mice, and pharmacological blockade with thiazide diuretics have revealed that reduced activity of the NaCl cotransporter (NCC) promotes renal Mg(2+) wasting. NCC is expressed along the distal convoluted tubule (DCT), and its activity determines Mg(2+)...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Renal Physiol
Hoofdauteurs: Maeoka, Yujiro, McCormick, James A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792700/
https://ncbi.nlm.nih.gov/pubmed/33135481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00463.2020
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