Histone deacetylase 6 inhibition mitigates renal fibrosis by suppressing TGF-β and EGFR signaling pathways in obstructive nephropathy

We have recently shown that histone deacetylase 6 (HDAC6) is critically involved in the pathogenesis of acute kidney injury. Its role in renal fibrosis, however, remains unclear. In this study, we examined the effect of ricolinostat (ACY-1215), a selective inhibitor of HDAC6, on the development of r...

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Publicado en:Am J Physiol Renal Physiol
Autores principales: Chen, Xingying, Yu, Chao, Hou, Xiying, Li, Jialu, Li, Tingting, Qiu, Andong, Liu, Na, Zhuang, Shougang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792693/
https://ncbi.nlm.nih.gov/pubmed/33103445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00261.2020
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