Inhibition of 15-PGDH prevents ischemic renal injury by the PGE(2)/EP(4) signaling pathway mediating vasodilation, increased renal blood flow, and increased adenosine/A(2A) receptors

In the present study, we demonstrated the marked activity of SW033291, an inhibitor of 15-hydoxyprostaglandin dehydrogenase (15-PGDH), in preventing acute kidney injury (AKI) in a murine model of ischemia-reperfusion injury. AKI due to ischemic injury represents a significant clinical problem. PGE(2...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Kim, Hye Jung, Kim, Sun-Hee, Kim, Minjung, Baik, HyungJoo, Park, Seok Ju, Kang, Mi Seon, Kim, Dong-Hyun, Kim, Byeong Woo, Markowitz, Sanford D., Bae, Ki Beom
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792690/
https://ncbi.nlm.nih.gov/pubmed/33135478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00103.2020
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