Impaired 25-hydroxylation of vitamin D in liver injury suppresses intestinal Paneth cell defensins, leading to gut dysbiosis and liver fibrogenesis

Vitamin D deficiency is coprevalent with various liver diseases, including cirrhosis, whereas the underlying mechanism remains elusive. Vitamin D receptor (VDR) is abundantly expressed in the distal region of the small intestine, where the Paneth cells are enriched, suggesting that vitamin D signali...

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Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Wu, Pengfei, Zhang, Ruofei, Luo, Mei, Zhang, Tianci, Pan, Lisha, Xu, Siya, Pan, Liwei, Ren, Feng, Ji, Cheng, Hu, Richard, Noureddin, Mazen, Pandol, Stephen J., Han, Yuan-Ping
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792671/
https://ncbi.nlm.nih.gov/pubmed/33084400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00021.2020
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