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14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model
Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies. αSyn is hypothesized to misfold and spread throughout the brain in...
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| Udgivet i: | Acta Neuropathol Commun |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7792107/ https://ncbi.nlm.nih.gov/pubmed/33413679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01110-5 |
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