PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner

BACKGROUND: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4-dependent manner, and its activity modulates the PEP/Ca(2+) signaling axis, pr...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Hyroššová, Petra, Aragó, Marc, Moreno-Felici, Juan, Fu, Xiarong, Mendez-Lucas, Andrés, García-Rovés, Pablo M., Burgess, Shawn, Figueras, Agnès, Viñals, Francesc, Perales, Jose C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791766/
https://ncbi.nlm.nih.gov/pubmed/33413684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-020-00236-3
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