Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer

Overcoming local immunosuppression is critical for immunotherapy to produce robust anti-tumor responses. Myeloid-derived suppressor cells (MDSCs) are key regulators of immunosuppressive networks and promote tumor progression. However, it remains unclear whether and how tumor-infiltrating MDSCs are s...

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Veröffentlicht in:Signal Transduct Target Ther
Hauptverfasser: Chen, Jing, Sun, Hong-Wei, Yang, Yan-Yan, Chen, Hai-Tian, Yu, Xing-Juan, Wu, Wen-Chao, Xu, Yi-Tuo, Jin, Li-Lian, Wu, Xiao-Jun, Xu, Jing, Zheng, Limin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791142/
https://ncbi.nlm.nih.gov/pubmed/33414378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-00377-3
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