Targeting autocrine CCL5-CCR5 axis reprograms immunosuppressive myeloid cells and reinvigorates antitumor immunity

The tumor-promoting potential of CCL5 has been proposed but remains poorly understood. We demonstrate here that an autocrine CCL5-CCR5 axis is a major regulator of immunosuppressive myeloid cells (IMC) of both monocytic and granulocytic lineages. The absence of the autocrine CCL5 abrogated the gener...

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發表在:Cancer Res
Main Authors: Ban, Yi, Mai, Junhua, Li, Xin, Mitchell-Flack, Marisa, Zhang, Tuo, Zhang, Lixing, Chouchane, Lotfi, Ferrari, Mauro, Shen, Haifa, Ma, Xiaojing
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484057/
https://ncbi.nlm.nih.gov/pubmed/28416485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2913
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