STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA is unclear. Previous research demonstrated that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) participates in DNA damage respon...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Guo, Qiang, Chen, Ximiao, Chen, Jiaoxiang, Zheng, Gang, Xie, Chenglong, Wu, Hongqiang, Miao, Zhimin, Lin, Yan, Wang, Xiangyang, Gao, Weiyang, Zheng, Xiangtao, Pan, Zongyou, Zhou, Yifei, Wu, Yaosen, Zhang, Xiaolei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791051/
https://ncbi.nlm.nih.gov/pubmed/33414452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03341-9
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