Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prothrombotic state and a lack of host anti-tumor immune responsiveness. Linking these two key features, we previously demonstrated that tumor-derived coagulation activity promotes immune evasion. Specifically, thrombin-protea...

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Veröffentlicht in:J Thromb Haemost
Hauptverfasser: Schweickert, Patrick G., Yang, Yi, White, Emily E., Cresswell, Gregory M., Elzey, Bennett D., Ratliff, Timothy L., Arumugam, Paritha, Antoniak, Silvio, Mackman, Nigel, Flick, Matthew J., Konieczny, Stephen F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790967/
https://ncbi.nlm.nih.gov/pubmed/33064371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15115
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