Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer

Patients with long-term estrogen-deprived breast cancer (BC), after resistance to tamoxifen or aromatase inhibitors develops, can experience tumor regression when treated with estrogens. Estrogen’s anti-tumor effect is attributed to apoptosis via the estrogen receptor (ER). Estrogen treatment can ha...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Abderrahman, Balkees, Maximov, Philipp Y., Curpan, Ramona F., Fanning, Sean W., Hanspal, Jay S., Fan, Ping, Foulds, Charles E., Chen, Yue, Malovannaya, Anna, Jain, Antrix, Xiong, Rui, Greene, Geoffrey L., Tonetti, Debra A., Thatcher, Gregory R. J., Jordan, V. Craig
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790886/
https://ncbi.nlm.nih.gov/pubmed/33177154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0563
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