Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers

Genes involved in 3′-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt branchpoint recognition leading to usage of cryptic 3′-splice sites and subsequent aberrant junctions...

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Veröffentlicht in:Oncogene
Hauptverfasser: Alsafadi, Samar, Dayot, Stephane, Tarin, Malcy, Houy, Alexandre, Bellanger, Dorine, Cornella, Michele, Wassef, Michel, Waterfall, Joshua J., Lehnert, Erik, Roman-Roman, Sergio, Stern, Marc-Henri, Popova, Tatiana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790757/
https://ncbi.nlm.nih.gov/pubmed/33057152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01507-5
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