Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers

Genes involved in 3′-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt branchpoint recognition leading to usage of cryptic 3′-splice sites and subsequent aberrant junctions...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Alsafadi, Samar, Dayot, Stephane, Tarin, Malcy, Houy, Alexandre, Bellanger, Dorine, Cornella, Michele, Wassef, Michel, Waterfall, Joshua J., Lehnert, Erik, Roman-Roman, Sergio, Stern, Marc-Henri, Popova, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790757/
https://ncbi.nlm.nih.gov/pubmed/33057152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01507-5
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