Functional and conformational impact of cancer-associated SF3B1 mutations depends on the position and the charge of amino acid substitution

The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers, contribute to oncogenesis by corrupting the mRNA splicing. Further SF3B1 mutations have been reported in cancers but their consequences remain unclear. Here, we screened for SF3B1 mutations in the vicinity of the h...

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Veröffentlicht in:Comput Struct Biotechnol J
Hauptverfasser: Canbezdi, Christine, Tarin, Malcy, Houy, Alexandre, Bellanger, Dorine, Popova, Tatiana, Stern, Marc-Henri, Roman-Roman, Sergio, Alsafadi, Samar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Research Network of Computational and Structural Biotechnology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960499/
https://ncbi.nlm.nih.gov/pubmed/33777335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.02.012
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