Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

Hotspot mutations in the spliceosome gene SF3B1 are reported in ∼20% of uveal melanomas. SF3B1 is involved in 3′-splice site (3′ss) recognition during RNA splicing; however, the molecular mechanisms of its mutation have remained unclear. Here we show, using RNA-Seq analyses of uveal melanoma, that t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Alsafadi, Samar, Houy, Alexandre, Battistella, Aude, Popova, Tatiana, Wassef, Michel, Henry, Emilie, Tirode, Franck, Constantinou, Angelos, Piperno-Neumann, Sophie, Roman-Roman, Sergio, Dutertre, Martin, Stern, Marc-Henri
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743009/
https://ncbi.nlm.nih.gov/pubmed/26842708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10615
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