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Platform to Discover Protease-Activated Antibiotics and Application to Siderophore–Antibiotic Conjugates
Here we present a platform for discovery of protease-activated prodrugs and apply it to antibiotics that target Gram-negative bacteria. Because cleavable linkers for prodrugs had not been developed for bacterial proteases, we used substrate phage to discover substrates for proteases found in the bac...
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| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7790458/ https://ncbi.nlm.nih.gov/pubmed/33301681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06987 |
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