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Development of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic Conjugates

Siderophore-antibiotic conjugates have increased in vitro activity in low-iron environments where bacteria express siderophores and associated transporters. The host immune hypoferremic response reduces iron availability to bacteria; however, patients with iron overload or deficiency may have altere...

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Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Kidd, James M., Abdelraouf, Kamilia, Nicolau, David P.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187605/
https://ncbi.nlm.nih.gov/pubmed/31658967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01961-19
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