Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort

BACKGROUND: Elevated triglycerides (TG) are associated with, and may be causal for, cardiovascular disease (CVD), and co-morbidities such as type II diabetes and metabolic syndrome. Pathogenic variants in APOA5 and APOC3 as well as risk SNVs in other genes [APOE (rs429358, rs7412), APOA1/C3/A4/A5 ge...

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Publicat a:BMC Med Genomics
Autors principals: Rosenthal, Elisabeth A., Crosslin, David R., Gordon, Adam S., Carrell, David S., Stanaway, Ian B., Larson, Eric B., Grafton, Jane, Wei, Wei-Qi, Denny, Joshua C., Feng, Qi-Ping, Shah, Amy S., Sturm, Amy C., Ritchie, Marylyn D., Pacheco, Jennifer A., Hakonarson, Hakon, Rasmussen-Torvik, Laura J., Connolly, John J., Fan, Xiao, Safarova, Maya, Kullo, Iftikhar J., Jarvik, Gail P.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789246/
https://ncbi.nlm.nih.gov/pubmed/33407432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-020-00854-2
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