DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism

Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used incretin-based therapy for the treatment of type 2 diabetes. We investigated the cardioprotective effect of a DPP-4 inhibitor, vildagliptin (vilda), on myocardial metabolism and cardiac performance under pressure overload. Mice were treated w...

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Bibliografiske detaljer
Udgivet i:Heart Vessels
Main Authors: Furukawa, Nozomi, Koitabashi, Norimichi, Matsui, Hiroki, Sunaga, Hiroaki, Umbarawan, Yogi, Syamsunarno, Mas Rizky A. A., Yamaguchi, Aiko, Obokata, Masaru, Hanaoka, Hirofumi, Yokoyama, Tomoyuki, Kurabayashi, Masahiko
Format: Artigo
Sprog:Inglês
Udgivet: Springer Japan 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788045/
https://ncbi.nlm.nih.gov/pubmed/33073318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00380-020-01711-z
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