Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function

Adult T-cell leukemia/lymphoma (ATLL) patients have an extremely poor prognosis, partly due to their immunosuppressive state. The majority of ATLL patients have leukemic cells with phenotype similar to Tregs, prompting suggestions that ATLL cells themselves have immunosuppressive functions. In this...

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Veröffentlicht in:Leukemia
Hauptverfasser: Nagate, Yasuhiro, Ezoe, Sachiko, Fujita, Jiro, Okuzaki, Daisuke, Motooka, Daisuke, Ishibashi, Tomohiko, Ichii, Michiko, Tanimura, Akira, Kurashige, Masako, Morii, Eiichi, Fukushima, Takuya, Suehiro, Youko, Yokota, Takafumi, Shibayama, Hirohiko, Oritani, Kenji, Kanakura, Yuzuru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787980/
https://ncbi.nlm.nih.gov/pubmed/32203145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0788-y
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