Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype

Cellular senescence has evolved as a protective mechanism to arrest growth of cells with oncogenic potential but is accompanied by the often pathologically deleterious senescence-associated secretory phenotype (SASP). Here we demonstrate an H(2)O(2)-dependent functional disruption controlling senesc...

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Detalhes bibliográficos
Publicado no:Exp Biol Med (Maywood)
Main Authors: Chandrasekaran, Akshaya, Lee, May Y, Zhang, Xuexin, Hasan, Shaheen, Desta, Habben, Tenenbaum, Scott A, Melendez, J Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787549/
https://ncbi.nlm.nih.gov/pubmed/32686475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370220943122
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