Redox Control of the Senescence Regulator Interleukin-1α and the Secretory Phenotype

Senescent cells accumulate in aged tissue and are causally linked to age-associated tissue degeneration. These non-dividing, metabolically active cells are highly secretory and alter tissue homeostasis, creating an environment conducive to metastatic disease progression. IL-1α is a key senescence-as...

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Hlavní autoři: McCarthy, Donald A., Clark, Ryan R., Bartling, Toni R., Trebak, Mohamed, Melendez, J. Andres
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820855/
https://ncbi.nlm.nih.gov/pubmed/24062309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.493841
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