Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

PURPOSE: This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and established a phase II dose for patients with untreated stage IV metastatic pancreatic ductal adenocarcinoma (PDA). Objective response...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Hingorani, Sunil R., Harris, William P., Beck, J. Thaddeus, Berdov, Boris A., Wagner, Stephanie A., Pshevlotsky, Eduard M., Tjulandin, Sergei A., Gladkov, Oleg A., Holcombe, Randall F., Korn, Ronald, Raghunand, Natarajan, Dychter, Samuel, Jiang, Ping, Shepard, H. Michael, Devoe, Craig E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787348/
https://ncbi.nlm.nih.gov/pubmed/26813359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2010
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