Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

PURPOSE: This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and established a phase II dose for patients with untreated stage IV metastatic pancreatic ductal adenocarcinoma (PDA). Objective response...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Hingorani, Sunil R., Harris, William P., Beck, J. Thaddeus, Berdov, Boris A., Wagner, Stephanie A., Pshevlotsky, Eduard M., Tjulandin, Sergei A., Gladkov, Oleg A., Holcombe, Randall F., Korn, Ronald, Raghunand, Natarajan, Dychter, Samuel, Jiang, Ping, Shepard, H. Michael, Devoe, Craig E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7787348/
https://ncbi.nlm.nih.gov/pubmed/26813359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2010
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