Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313

PURPOSE: Pegylated recombinant human hyaluronidase (PEGPH20) degrades hyaluronan (HA) and, in combination with chemotherapy, prolongs survival in preclinical models. The activity of PEGPH20 with modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) was evaluated in patients wi...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Ramanathan, Ramesh K., McDonough, Shannon L., Philip, Philip A., Hingorani, Sunil R., Lacy, Jill, Kortmansky, Jeremy S., Thumar, Jaykumar, Chiorean, E. Gabriela, Shields, Anthony F., Behl, Deepti, Mehan, Paul T., Gaur, Rakesh, Seery, Tara, Guthrie, Katherine A., Hochster, Howard S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494359/
https://ncbi.nlm.nih.gov/pubmed/30817250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.18.01295
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