Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis

Achieving immunoregulation via in vivo expansion of Foxp3(+) regulatory CD4(+) T cells (Treg) remains challenging. We have shown that mobilization confers to multipotent hematopoietic progenitors (MPPs) the capacity to enhance Treg proliferation. Transcriptomic analysis of Tregs co-cultured with MPP...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Korniotis, Sarantis, D’Aveni, Maud, Hergalant, Sébastien, Letscher, Hélène, Tejerina, Emmanuel, Gastineau, Pauline, Agbogan, Viviane A., Gras, Christophe, Fouquet, Guillemette, Rossignol, Julien, Chèvre, Jean-Claude, Cagnard, Nicolas, Rubio, Marie-Thérèse, Hermine, Olivier, Zavala, Flora
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786289/
https://ncbi.nlm.nih.gov/pubmed/33424854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.607175
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