Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols

Human tyrosyl-DNA phosphodiesterase 1 (TDP1) belongs to the phospholipase D superfamily, whose members contain paired catalytic histidine and lysine residues within two conserved motifs and hydrolyze phosphodiester bonds. TDP1 is a DNA repair enzyme that processes 3′ DNA end blocking lesions and a w...

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Dettagli Bibliografici
Pubblicato in:Front Cell Dev Biol
Autori principali: Dyrkheeva, Nadezhda, Anarbaev, Rashid, Lebedeva, Natalia, Kuprushkin, Maxim, Kuznetsova, Alexandra, Kuznetsov, Nikita, Rechkunova, Nadejda, Lavrik, Olga
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cell and Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786179/
https://ncbi.nlm.nih.gov/pubmed/33425909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.604732
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