Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2′,3′,5′-tri-O-benzoyl-d-ribofuran...

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Publicat a:Molecules
Autors principals: Zakharenko, Alexandra L., Drenichev, Mikhail S., Dyrkheeva, Nadezhda S., Ivanov, Georgy A., Oslovsky, Vladimir E., Ilina, Ekaterina S., Chernyshova, Irina A., Lavrik, Olga I., Mikhailov, Sergey N.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7465190/
https://ncbi.nlm.nih.gov/pubmed/32823658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163694
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