Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2′,3′,5′-tri-O-benzoyl-d-ribofuran...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Molecules
Prif Awduron: Zakharenko, Alexandra L., Drenichev, Mikhail S., Dyrkheeva, Nadezhda S., Ivanov, Georgy A., Oslovsky, Vladimir E., Ilina, Ekaterina S., Chernyshova, Irina A., Lavrik, Olga I., Mikhailov, Sergey N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7465190/
https://ncbi.nlm.nih.gov/pubmed/32823658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163694
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