Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis

Liver fibrosis is an increasing health problem worldwide, for which no effective antifibrosis drugs are available. Although the involvement of aerobic glycolysis in hepatic stellate cell (HSC) activation has been reported, the role of pyruvate kinase M2 (PKM2) in liver fibrogenesis still remains unk...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Zheng, Dandan, Jiang, Yuchuan, Qu, Chen, Yuan, Hui, Hu, Kaishun, He, Lu, Chen, Peng, Li, Jinying, Tu, Mengxian, Lin, Lehang, Chen, Hengxing, Lin, Zelong, Lin, Wenyu, Fan, Jun, Cheng, Guohua, Hong, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2020
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786052/
https://ncbi.nlm.nih.gov/pubmed/32805235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.08.002
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