“Bromodomain-containing-protein-4 and Cyclin-Dependent-Kinase-9 Inhibitors Interact Synergistically in-vitro and Combined Treatment Reduces Post-Traumatic Osteoarthritis Severity in Mice”

OBJECTIVE. Joint injury rapidly induces expression of primary response genes (PRGs), which activate a cascade of secondary genes that destroy joint tissues and initiate post-traumatic osteoarthritis (PTOA). Bromodomain-containing-protein-4 (Brd4) and cyclin-dependent-kinase-9 (CDK9) cooperatively co...

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Veröffentlicht in:Osteoarthritis Cartilage
Hauptverfasser: Fukui, Tomoaki, Yik, Jasper H. N., Doyran, Basak, Davis, Jack, Haudenschild, Anne K., Adamopoulos, Iannis E., Han, Lin, Haudenschild, Dominik R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785706/
https://ncbi.nlm.nih.gov/pubmed/33164842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2020.07.012
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