Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway

Intervertebral disk degeneration (IVDD) is a spinal disk condition caused by an inflammatory response induced by various proinflammatory cytokines, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α. cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential therapeutic...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Ni, Weiyu, Zhang, Feizhou, Zheng, Lin, Wang, Lili, Liang, Yi, Ding, Yuhong, Yik, Jasper H. N., Haudenschild, Dominik R., Fan, Shunwu, Hu, Ziang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511812/
https://ncbi.nlm.nih.gov/pubmed/33015073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.579658
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