Activin A promotes regulatory T cell–mediated immunosuppression in irradiated breast cancer

Increased regulatory T cells (Tregs) after radiation therapy have been reported, but the mechanisms of their induction remain incompletely understood. TGFβ is known to foster Treg differentiation within tumors and is activated following radiation therapy. Thus, we hypothesized that TGFβ blockade wou...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Res
Main Authors: De Martino, Mara, Daviaud, Camille, Diamond, Julie M, Kraynak, Jeffrey, Alard, Amandine, Formenti, Silvia C, Miller, Lance D, Demaria, Sandra, Vanpouille-Box, Claire
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785684/
https://ncbi.nlm.nih.gov/pubmed/33093219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0305
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