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Extracellular matrix-bound FGF2 mediates estrogen receptor signaling and therapeutic response in breast cancer

The extracellular matrix (ECM) is often unaccounted for in studies that consider the stromal contribution to cancer cell signaling and response to treatment. To investigate the influence of a fibrotic microenvironment we utilize fibroblast-derived ECM scaffolds as a cell culture platform. We uncover...

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Publicat a:Mol Cancer Res
Autors principals: DiGiacomo, Josh W., Godet, Inês, Trautmann-Rodriguez, Michael, Gilkes, Daniele M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785668/
https://ncbi.nlm.nih.gov/pubmed/33033110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0554
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