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Extracellular matrix-bound FGF2 mediates estrogen receptor signaling and therapeutic response in breast cancer

The extracellular matrix (ECM) is often unaccounted for in studies that consider the stromal contribution to cancer cell signaling and response to treatment. To investigate the influence of a fibrotic microenvironment we utilize fibroblast-derived ECM scaffolds as a cell culture platform. We uncover...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: DiGiacomo, Josh W., Godet, Inês, Trautmann-Rodriguez, Michael, Gilkes, Daniele M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785668/
https://ncbi.nlm.nih.gov/pubmed/33033110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0554
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