Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer’s disease (AD) pathology. Altered mitochondrial homeostasis is considered an early event in AD development. However, the specif...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Vaillant-Beuchot, Loan, Mary, Arnaud, Pardossi-Piquard, Raphaëlle, Bourgeois, Alexandre, Lauritzen, Inger, Eysert, Fanny, Kinoshita, Paula Fernanda, Cazareth, Julie, Badot, Céline, Fragaki, Konstantina, Bussiere, Renaud, Martin, Cécile, Mary, Rosanna, Bauer, Charlotte, Pagnotta, Sophie, Paquis-Flucklinger, Véronique, Buée-Scherrer, Valérie, Buée, Luc, Lacas-Gervais, Sandra, Checler, Frédéric, Chami, Mounia
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785558/
https://ncbi.nlm.nih.gov/pubmed/33079262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02234-7
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