AMPK, a key regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin-directed ubiquitin signal transduction system

AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel lectins detect membrane damage leading to ubiquitination responses. Absence of Galectin 9 (Gal9)...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Jia, Jingyue, Bissa, Bhawana, Brecht, Lukas, Allers, Lee, Choi, Seong Won, Gu, Yuexi, Zbinden, Mark, Burge, Mark R., Timmins, Graham, Hallows, Kenneth, Behrends, Christian, Deretic, Vojo
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785494/
https://ncbi.nlm.nih.gov/pubmed/31995728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.12.028
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