AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system

Lysosomal damage activates AMPK, a regulator of macroautophagy/autophagy and metabolism, and elicits a strong ubiquitination response. Here we show that the cytosolic lectin LGALS9 detects lysosomal membrane breach by binding to lumenal glycoepitopes, and directs both the ubiquitination response and...

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Publicat a:Autophagy
Autors principals: Jia, Jingyue, Bissa, Bhawana, Brecht, Lukas, Allers, Lee, Choi, Seong Won, Gu, Yuexi, Zbinden, Mark, Burge, Mark R., Timmins, Graham, Hallows, Kenneth, Behrends, Christian, Deretic, Vojo
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
Matèries:
Autophagic Punctum
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469532/
https://ncbi.nlm.nih.gov/pubmed/32597364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1788890
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