MDA5 is an essential vita-PAMP sensor necessary for host resistance against Aspergillus fumigatus

RIG-I like receptors (RLR) are cytosolic RNA sensors that signal through the MAVS adaptor to activate interferon responses against viruses. Whether the RLR family has broader effects on host immunity against other pathogen families remains to be fully explored. Herein we demonstrate that MDA5/MAVS s...

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Veröffentlicht in:J Immunol
Hauptverfasser: Wang, Xi, Caffrey-Carr, Alayna K., Liu, Ko-wei, Espinosa, Vanessa, Croteau, Walburga, Dhingra, Sourabh, Rivera, Amariliz, Cramer, Robert A., Obar, Joshua J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785165/
https://ncbi.nlm.nih.gov/pubmed/33087405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000802
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