Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

Notch signaling plays important roles in the regulation of immune cell functioning during the inflammatory response. Activation of the innate immune signaling receptor NLRP3 promotes inflammation in injured tissue. However, it remains unknown whether Jagged1 (JAG1)-mediated myeloid Notch1 signaling...

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Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Jin, Yuting, Li, Changyong, Xu, Dongwei, Zhu, Jianjun, Wei, Song, Zhong, Andrew, Sheng, Mingwei, Duarte, Sergio, Coito, Ana J., Busuttil, Ronald W., Xia, Qiang, Kupiec-Weglinski, Jerzy W., Ke, Bibo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784844/
https://ncbi.nlm.nih.gov/pubmed/31673056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0318-x
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