Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A

Inspired by the cytotoxicity of perphenazine toward cancer cells and its ability to activate the serine/threonine protein phosphatase 2A (PP2A), we prepared series of ether-carbon linked analogs of a constrained synthetic sphingolipid analog 3, known for its cytotoxicity, nutrient transporter down-r...

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Publicado en:Bioorg Med Chem Lett
Main Authors: Garsi, Jean-Baptiste, Vece, Vito, Sernissi, Lorenzo, Auger-Morin, Catherine, Hanessian, Stephen, McCracken, Alison N., Selwan, Elizabeth, Ramirez, Cuauhtemoc, Dahal, Amogha, Romdhane, Nadine Ben, Finicle, Brendan T., Edinger, Aimee L.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784717/
https://ncbi.nlm.nih.gov/pubmed/31383588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.07.023
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