Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A

Inspired by the cytotoxicity of perphenazine toward cancer cells and its ability to activate the serine/threonine protein phosphatase 2A (PP2A), we prepared series of ether-carbon linked analogs of a constrained synthetic sphingolipid analog 3, known for its cytotoxicity, nutrient transporter down-r...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Garsi, Jean-Baptiste, Vece, Vito, Sernissi, Lorenzo, Auger-Morin, Catherine, Hanessian, Stephen, McCracken, Alison N., Selwan, Elizabeth, Ramirez, Cuauhtemoc, Dahal, Amogha, Romdhane, Nadine Ben, Finicle, Brendan T., Edinger, Aimee L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784717/
https://ncbi.nlm.nih.gov/pubmed/31383588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.07.023
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky